Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6904741 | 0.80 | AOC3 (0.50) | MAPTLMNASMN1; SMN2MAPK1POLB | |
| SCHEMBL31484255 | 0.77 | KDM4E (0.42) | MAPTLMNASMN1; SMN2POLBKDM4E | |
| SCHEMBL1032325 | 0.72 | CA12 (0.50) | LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL31484258 | 0.70 | GRIN2D (0.33) | SMN1; SMN2ICMTHSD17B10 | |
| SCHEMBL28142858 | 0.69 | HSD17B10 (0.50) | MAPTLMNAMAPK1KDM4EHSD17B10 | |
| SCHEMBL1599374 | 0.68 | CYP2C9 (0.56) | MAPTLMNAICMTKDM4EHSD17B10 | |
| SCHEMBL1461671 | 0.67 | KDM4E (0.49) | MAPTSMN1; SMN2POLBKDM4ECTDSP1 | |
| SCHEMBL7151000 | 0.66 | KDM4E (0.51) | MAPTSMN1; SMN2POLBKDM4ECTDSP1 | |
| SCHEMBL1010680 | 0.66 | LMNA (0.64) | MAPTLMNASMN1; SMN2POLBKDM4E | |
| SCHEMBL3456256 | 0.66 | KMT2A (0.56) | LMNASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025068461-A1 | GUANFACINE DERIVATIVES AND THEIR USE IN TREATING CANCER | NEGIO THERAPEUTICS (BE) | 2025-04-03 | — | — | WO | claimed |
| WO-2025068461-A1 | GUANFACINE DERIVATIVES AND THEIR USE IN TREATING CANCER | NEGIO THERAPEUTICS (BE) | 2025-04-03 | — | — | WO | disclosed |