Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ICMT | O60725 | 6/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120045 | 0.77 | HTT (0.38) | HTTICMTUSP2ALOX15CASP1 | |
| SCHEMBL31484256 | 0.70 | MAPT (0.39) | ICMTHSD17B10SMN1; SMN2 | |
| SCHEMBL9688908 | 0.69 | L3MBTL1 (0.35) | HTTICMTALDH1A1 | |
| SCHEMBL339508 | 0.68 | P2RX7 (0.44) | ICMTHSD17B10ALDH1A1 | |
| SCHEMBL28176483 | 0.68 | HTT (0.37) | HTTICMTHSD17B10CA2ALDH1A1 | |
| SCHEMBL17979828 | 0.67 | CASP1 (0.45) | HTTICMTCASP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL23370334 | 0.67 | KDM4E (0.30) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL14167164 | 0.67 | P2RX7 (0.43) | ICMTHSD17B10ALDH1A1 | |
| SCHEMBL2702114 | 0.65 | ICMT (0.45) | HTTICMTCA2 | |
| SCHEMBL30570712 | 0.65 | TAAR1 (0.52) | HTTICMTCA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025068461-A1 | GUANFACINE DERIVATIVES AND THEIR USE IN TREATING CANCER | NEGIO THERAPEUTICS (BE) | 2025-04-03 | — | — | WO | claimed |
| WO-2025068461-A1 | GUANFACINE DERIVATIVES AND THEIR USE IN TREATING CANCER | NEGIO THERAPEUTICS (BE) | 2025-04-03 | — | — | WO | disclosed |