Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31484256 | 0.77 | MAPT (0.39) | KDM4ELMNAPOLBMAPTSMN1; SMN2 | |
| SCHEMBL1032325 | 0.75 | CA12 (0.50) | LMNANFE2L2CA1CA2ALDH1A1 | |
| SCHEMBL29639810 | 0.74 | ALDH1A1 (0.41) | MTNR1AALDH1A1 | |
| SCHEMBL4685087 | 0.74 | ALDH1A1 (0.42) | KDM4ELMNAALDH1A1 | |
| SCHEMBL2315019 | 0.73 | CA1 (0.61) | KDM4EHPGDLMNAPOLBNFE2L2 | |
| SCHEMBL2318116 | 0.72 | KDM4E (0.58) | KDM4EHPGDLMNANFE2L2MAPT | |
| SCHEMBL2235848 | 0.69 | MAPT (0.42) | KDM4EHPGDLMNAMAPTHTT | |
| SCHEMBL6904741 | 0.67 | AOC3 (0.50) | KDM4ELMNAPOLBMAPTALDH1A1 | |
| SCHEMBL1010680 | 0.66 | LMNA (0.64) | KDM4ELMNAPOLBMAPTSMN1; SMN2 | |
| SCHEMBL9504003 | 0.66 | MTNR1A (0.47) | KDM4EHPGDLMNAMTNR1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025068461-A1 | GUANFACINE DERIVATIVES AND THEIR USE IN TREATING CANCER | NEGIO THERAPEUTICS (BE) | 2025-04-03 | — | — | WO | claimed |
| WO-2025068461-A1 | GUANFACINE DERIVATIVES AND THEIR USE IN TREATING CANCER | NEGIO THERAPEUTICS (BE) | 2025-04-03 | — | — | WO | disclosed |