SCHEMBL31485375

SCHEMBL31485375

O=C(Nc1cc(N2CCC(F)(F)CC2)c2nccnc2c1)c1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC1)CC2

nearest known ligand 0.75

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26650663 1.00 KIF18A (0.75) KIF18A
SCHEMBL26650639 0.88 KIF18A (0.70) KIF18A
SCHEMBL30748615 0.88 KIF18A (0.70) KIF18A
SCHEMBL26650561 0.87 KIF18A (0.72) KIF18A
SCHEMBL30748583 0.87 KIF18A (0.72) KIF18A
SCHEMBL26651075 0.87 KIF18A (0.72) KIF18A
SCHEMBL22148704 0.85 KIF18A (1.00) KIF18A
SCHEMBL29370639 0.85 KIF18A (1.00) KIF18A
SCHEMBL30748626 0.85 KIF18A (0.70) KIF18A
SCHEMBL26650694 0.85 KIF18A (0.70) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4524135-A1 KINESIN KIF18A INHIBITOR AND USE THEREOF Shanghai Apeiron Therapeutics Company Limited (CN) 2025-03-19 — — EP disclosed
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