Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monomethyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 known ✓ | Q14145 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 10/20 | 0.68 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethyl Maleate SCHEMBL19690393 | 0.82 | HCAR2 (1.00) | HCAR2NFE2L2KEAP1ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL28468249 | 0.82 | HCAR2 (1.00) | HCAR2NFE2L2KEAP1ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL60133 | 0.82 | — | — | |
| Monomethyl Fumarate SCHEMBL126468 | 0.82 | — | — | |
| Dimethyl Fumarate SCHEMBL15573963 | 0.82 | HCAR2 (1.00) | HCAR2NFE2L2KEAP1ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL25280962 | 0.82 | HCAR2 (1.00) | HCAR2NFE2L2KEAP1ALDH1A1MAPT | |
| Dimethyl Fumarate SCHEMBL15573962 | 0.82 | HCAR2 (1.00) | HCAR2NFE2L2KEAP1ALDH1A1MAPT | |
| Dimethyl Maleate SCHEMBL6896824 | 0.82 | HCAR2 (1.00) | HCAR2NFE2L2KEAP1ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL60132 | 0.82 | — | — | |
| Monomethyl Fumarate SCHEMBL28037664 | 0.82 | HCAR2 (1.00) | HCAR2NFE2L2KEAP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912264-B2 | Aqueous ethylene/vinyl alcohol copolymer dispersion | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-8664313-B2 | Method for producing aqueous ethylene/vinyl alcohol based copolymer dispersion | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2014-03-04 | — | — | US | disclosed |
| EP-1762585-B1 | METHOD FOR PRODUCING AQUEOUS ETHYLENE/VINYL ALCOHOL BASED COPOLYMER DISPERSION | SUMITOMO SEIKA CHEMICALS (JP) | 2010-12-08 | — | — | EP | disclosed |
| EP-1816159-B1 | AQUEOUS ETHYLENE/VINYL ALCOHOL COPOLYMER DISPERSION | SUMITOMO SEIKA CHEMICALS (JP) | 2010-02-24 | — | — | EP | disclosed |
| US-20090149593-A1 | AQUEOUS ETHYLENE/VINYL ALCOHOL COPOLYMER DISPERSION | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2009-06-11 | — | — | US | disclosed |
| US-20080176989-A1 | Method For Producing Aqueous Ethylene/Vinyl Alcohol Based Copolymer Dispersion | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2008-07-24 | — | — | US | disclosed |
| EP-1816159-A1 | AQUEOUS ETHYLENE/VINYL ALCOHOL COPOLYMER DISPERSION | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2007-08-08 | — | — | EP | disclosed |
| EP-1762585-A1 | METHOD FOR PRODUCING AQUEOUS ETHYLENE/VINYL ALCOHOL BASED COPOLYMER DISPERSION | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2007-03-14 | — | — | EP | disclosed |