SCHEMBL31487447

SCHEMBL31487447

COc1ccnc(C(=O)NC2CC3(CCN(CC4CCN(c5cc(OC)c(NC6CCC(=O)NC6=O)cc5F)CC4)CC3)C2)c1

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.39
CRBN Q96SW2 10/20 0.37
DDB1 Q16531 4/20 0.37
GPR6 P46095 1/20 0.36
ACKR3 P25106 1/20 0.34
RIPK1 Q13546 3/20 0.34
FFAR4 Q5NUL3 1/20 0.33
BACE1 P56817 2/20 0.33
BACE2 Q9Y5Z0 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31487522 0.89 CRBN (0.39) ARCRBNDDB1FFAR4
SCHEMBL31487487 0.89 CCR3 (0.38) ARCRBNDDB1
SCHEMBL30478991 0.85 AR (0.39) ARCRBNDDB1GPR6ACKR3
SCHEMBL31487523 0.85 CRBN (0.40) ARCRBNDDB1GPR6FFAR4
SCHEMBL31487395 0.85 CCR3 (0.39) ARCRBNDDB1
SCHEMBL30965792 0.84 CRBN (0.41) ARCRBNDDB1FFAR4
SCHEMBL30965617 0.82 CA1 (0.38) ARCRBNDDB1FFAR4
SCHEMBL30965534 0.82 CRBN (0.43) CRBNDDB1FFAR4
SCHEMBL31487662 0.80 CRBN (0.40) CRBNDDB1GPR6
SCHEMBL30965684 0.79 DRD2 (0.39) ARCRBNDDB1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119790057-A Novel PLK1 degradation inducing compounds 厄普特拉株式会社 2025-04-08 CN disclosed