SCHEMBL31487889

SCHEMBL31487889

c1ccc(COc2ccc3ccnn3c2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.47
LMNA P02545 2/20 0.47
CYP1A2 P05177 1/20 0.47
PTGS1 P23219 1/20 0.47
SLC6A2 P23975 1/20 0.47
CYP2C19 P33261 1/20 0.47
PTGS2 P35354 1/20 0.47
SLC6A3 Q01959 1/20 0.47
HIF1A Q16665 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
RAB9A P51151 4/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
MAPT P10636 2/20 0.46
GAA P10253 1/20 0.46
MAOA P21397 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
ALOX5 P09917 1/20 0.45
CYP3A4 P08684 1/20 0.44
BCHE P06276 1/20 0.44
NPC1 O15118 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12750497 0.78 LMNA (0.45) MAOBLMNACYP1A2PTGS1SLC6A2
SCHEMBL25421011 0.78 DRD2 (0.45) CYP1A2CYP2C19RAB9ASMN1; SMN2MAPT
SCHEMBL31487829 0.76 MAPK14 (0.49) MAOBLMNACYP1A2PTGS1SLC6A2
SCHEMBL31011205 0.76 HDAC6 (0.47) MAOBLMNACYP1A2PTGS1SLC6A2
SCHEMBL24567001 0.74 DRD2 (0.54) CYP1A2CYP2C19RAB9ASMN1; SMN2MAOA
SCHEMBL3618652 0.73 DRD2 (0.50) CYP1A2CYP2C19CYP3A4DRD2DRD1
SCHEMBL31416740 0.73 RAB9A (0.43) MAOBLMNACYP1A2PTGS1SLC6A2
SCHEMBL2351198 0.73 MAOB (0.45) MAOBLMNACYP1A2PTGS1SLC6A2
SCHEMBL30725889 0.73 MAOB (0.52) MAOBLMNACYP1A2PTGS1SLC6A2
SCHEMBL339813 0.72 LMNA (0.82) MAOBLMNACYP1A2PTGS1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025089370-A1 COMPOUNDS AS CSF1R INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2025-05-01 WO disclosed