SCHEMBL31488038

SCHEMBL31488038

Cn1cc(-c2ccc3c(C4CCN(C(=O)OC(C)(C)C)CC4)cnn3c2)cn1

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ RET P07949 13/20 0.59
▸ GPR119 Q8TDV5 1/20 0.58
▸ USP30 Q70CQ3 2/20 0.52
▸ LRRK2 Q5S007 1/20 0.46
▸ HTT P42858 2/20 0.45
▸ MET P08581 1/20 0.45
▸ PDE3B Q13370 1/20 0.45
▸ PDE3A Q14432 1/20 0.45
▸ KDM4E B2RXH2 1/20 0.44
▸ MEN1 O00255 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ HPGD P15428 1/20 0.44
▸ TSHR P16473 1/20 0.44
▸ CRHBP P24387 1/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ CRHR2 Q13324 1/20 0.44
▸ HSD17B10 Q99714 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25413803 0.94 RET (0.55) RETGPR119USP30LRRK2MET
SCHEMBL31488194 0.89 GPR119 (0.48) RETGPR119HTTMETKDM4E
SCHEMBL31487765 0.86 GPR119 (0.56) RETGPR119HTTKDM4EMEN1
SCHEMBL31487843 0.84 RET (0.55) RETGPR119USP30
SCHEMBL31487545 0.84 MEN1 (0.45) RETGPR119HTTKDM4EMEN1
SCHEMBL31487886 0.84 RET (0.46) RETGPR119USP30HTTMET
SCHEMBL25416142 0.83 RET (0.62) RETGPR119USP30LRRK2MET
SCHEMBL31488149 0.83 MEN1 (0.54) MEN1ALDH1A1HPGDKMT2AHSD17B10
SCHEMBL31487750 0.83 ALDH1A1 (0.53) GPR119HTTKDM4EMEN1ALDH1A1
SCHEMBL31487833 0.82 KMT2A (0.48) GPR119HTTKDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025089370-A1 COMPOUNDS AS CSF1R INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2025-05-01 — — WO disclosed
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