SCHEMBL31489309

SCHEMBL31489309

CC(F)(F)C(c1ccc(F)cc1)n1cc(-c2cc(Cl)cc(F)c2F)cn1

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 10/20 0.34
CREBBP Q92793 2/20 0.34
KDM4E B2RXH2 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NTRK1 P04629 1/20 0.32
KCNH2 Q12809 2/20 0.32
AXL P30530 1/20 0.31
TYRO3 Q06418 1/20 0.31
MERTK Q12866 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489182 0.76 PDK2 (0.36) PDK2CREBBP
SCHEMBL31489229 0.76 PDK2 (0.36) PDK2CREBBP
SCHEMBL31489235 0.76 CCNE2 (0.33) KDM4ESMN1; SMN2
SCHEMBL31489637 0.74 MKNK1 (0.39) KDM4ESMN1; SMN2
SCHEMBL31489553 0.74 CYP11B2 (0.40) KDM4ESMN1; SMN2
SCHEMBL31489816 0.74 CYP11B2 (0.40) KDM4ESMN1; SMN2
SCHEMBL31489493 0.73 CREBBP (0.32) CREBBP
SCHEMBL31489550 0.72 CYP26A1 (0.30)
SCHEMBL31489410 0.72 CYP26A1 (0.30)
SCHEMBL31489649 0.72 CYP26A1 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed