SCHEMBL31489336

SCHEMBL31489336

Nc1nc2cc(I)c(F)cn2n1

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 5/20 0.38
PIK3CD O00329 3/20 0.34
PIK3CA P42336 1/20 0.33
PIK3CB P42338 1/20 0.33
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27037698 0.75 PIK3CG (0.40) PIK3CGPIK3CDPIK3CAPIK3CBKDM4E
SCHEMBL18916742 0.72 AHR (0.42)
SCHEMBL31489137 0.71 KDM4E (0.30) KDM4E
SCHEMBL16003429 0.69 KMT2A (0.42) PIK3CGKDM4EALDH1A1
SCHEMBL30842048 0.68 AHR (0.51) PIK3CGPIK3CDPIK3CAPIK3CB
SCHEMBL31489828 0.67 NUDT1 (0.34) PIK3CGPIK3CDPIK3CAPIK3CB
SCHEMBL12909576 0.67 PIK3CG (0.50) PIK3CGPIK3CDPIK3CAPIK3CBKDM4E
SCHEMBL24463575 0.67 DYRK1A (0.37)
SCHEMBL30888293 0.67 KDM4E (0.40) PIK3CGPIK3CDPIK3CAPIK3CBKDM4E
SCHEMBL27037213 0.67 CYP11B1 (0.46) PIK3CGPIK3CDPIK3CAPIK3CB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed