SCHEMBL31489425

SCHEMBL31489425

Cc1c(B2OC(C)(C)C(C)(C)O2)c(F)cn2nc(-n3c(C)ccc3C)nc12

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 2/20 0.31
BTK Q06187 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489290 0.81 LPL (0.34) JAK2BTK
SCHEMBL31489546 0.77 JAK2 (0.34) JAK2BTK
SCHEMBL31489677 0.76 JAK2 (0.34) JAK2BTK
SCHEMBL31489676 0.76 JAK2 (0.34) JAK2BTK
SCHEMBL31489436 0.76 JAK2 (0.33) JAK2BTK
SCHEMBL31489562 0.74 KDM4E (0.37)
SCHEMBL31489613 0.74 JAK2 (0.34) JAK2BTK
SCHEMBL31489440 0.71
SCHEMBL31489331 0.69 KDM4E (0.37)
SCHEMBL31489321 0.66 KDM4E (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed