SCHEMBL31489134

SCHEMBL31489134

Nc1nc2cc(-c3nccc(-c4cnn(C(CCF)c5ccc(F)cc5)c4)n3)ccn2n1

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
PIK3CG P48736 9/20 0.33
PIK3CD O00329 8/20 0.33
PIK3CA P42336 2/20 0.33
DYRK1B Q9Y463 1/20 0.32
MKNK1 Q9BUB5 1/20 0.32
RIPK1 Q13546 1/20 0.32
ROCK2 O75116 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489918 0.91 PIK3CG (0.33) PIK3CGPIK3CDPIK3CADYRK1BMKNK1
SCHEMBL31489335 0.89 PIK3CG (0.36) PIK3CGPIK3CDPIK3CAMKNK1RIPK1
SCHEMBL31489354 0.89 RIPK1 (0.36) PIK3CGPIK3CDPIK3CARIPK1ROCK2
SCHEMBL31489857 0.89 RIPK1 (0.36) PIK3CGPIK3CDPIK3CARIPK1ROCK2
SCHEMBL31489719 0.87 PIK3CG (0.38) PIK3CGPIK3CDPIK3CARIPK1
SCHEMBL31489667 0.87 PIK3CG (0.38) PIK3CGPIK3CDPIK3CARIPK1
SCHEMBL31489256 0.86 ROCK2 (0.32) MEN1GAAMAPTKMT2AL3MBTL1
SCHEMBL31489902 0.86 PIK3CG (0.36) PIK3CGPIK3CDPIK3CAMKNK1RIPK1
SCHEMBL31489307 0.84 PIK3CG (0.34) MEN1KMT2APIK3CGPIK3CDPIK3CA
SCHEMBL31489345 0.84 PIK3CG (0.34) MEN1KMT2APIK3CGPIK3CDPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed