SCHEMBL31489466

SCHEMBL31489466

CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nc2cc(-c3ccnc(Cl)c3F)ccn2n1

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
AAK1 Q2M2I8 1/20 0.36
GPBAR1 Q8TDU6 1/20 0.35
SSTR4 P31391 1/20 0.32
SYK P43405 1/20 0.31
TDP2 O95551 2/20 0.31
KAT7 O95251 1/20 0.31
ATR Q13535 1/20 0.30
KAT6A Q92794 1/20 0.30
KAT5 Q92993 1/20 0.30
KAT8 Q9H7Z6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31507885 0.85 TDP2 (0.31) TDP2KAT7KAT6AKAT5KAT8
SCHEMBL31489293 0.84 TDP2 (0.33) TDP2KAT7
SCHEMBL31507676 0.83 TDP2 (0.32) TDP2
SCHEMBL31507742 0.83 HSD17B14 (0.34) TDP2
SCHEMBL31489559 0.82 SSTR4 (0.34) SSTR4TDP2
SCHEMBL31507795 0.82 CSNK2A1 (0.32)
SCHEMBL25440010 0.81 CSNK2A2 (0.32)
SCHEMBL29498023 0.81 CSNK2A2 (0.32)
SCHEMBL31489812 0.81 TDP2 (0.34) AAK1TDP2
SCHEMBL25440052 0.80 CSNK2A2 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed