SCHEMBL31492986

SCHEMBL31492986

Cc1cc(O)cc(C(C)(F)F)n1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.38
HSP90AB1 P08238 1/20 0.38
GABRA1 P14867 1/20 0.33
GABRB2 P47870 1/20 0.33
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
RAD51 Q06609 1/20 0.31
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19023824 0.81 GABRA1 (0.34) GABRA1GABRB2
SCHEMBL31493136 0.75 HSP90AA1 (0.47) HSP90AA1HSP90AB1ALDH1A1LMNA
SCHEMBL275728 0.74
SCHEMBL27029966 0.71 KMT2A (0.44) HSP90AA1HSP90AB1ALDH1A1MAPTRAD51
SCHEMBL27269634 0.71 HSP90AA1 (0.42) HSP90AA1HSP90AB1LMNA
SCHEMBL19024202 0.68 MEN1 (0.31)
SCHEMBL8446958 0.67 HSP90AA1 (0.41) HSP90AA1HSP90AB1ALDH1A1LMNA
SCHEMBL29577064 0.67
SCHEMBL502316 0.67
SCHEMBL15144972 0.67 HSP90AA1 (0.38) HSP90AA1HSP90AB1MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119894879-A Tyrosine kinase 2 inhibitors and uses thereof 渤健马萨诸塞州股份有限公司 2025-04-25 CN disclosed
CN-119866338-A Tyrosine kinase 2 inhibitors and uses thereof 渤健马萨诸塞州股份有限公司 2025-04-22 CN disclosed
CN-119654322-A TYK2 inhibitors 渤健马萨诸塞州股份有限公司 2025-03-18 CN disclosed