Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 3/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2569082 | 0.87 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL30329080 | 0.84 | ADORA2A (0.38) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL1257925 | 0.78 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL31481300 | 0.76 | MEN1 (0.40) | HSP90AA1HSP90AB1LMNAALDH1A1GAA | |
| SCHEMBL22321661 | 0.74 | KIF11 (0.50) | LMNAPOLBALDH1A1GAAKDM4E | |
| SCHEMBL3291350 | 0.74 | CES2 (0.44) | HSP90AA1HSP90AB1LMNAALDH1A1BACE1 | |
| SCHEMBL24784677 | 0.72 | TRPV4 (0.46) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL8788157 | 0.72 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1POLBALDH1A1GAA | |
| SCHEMBL10271821 | 0.72 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1ALDH1A1GAAHTT | |
| SCHEMBL1965945 | 0.72 | KDM4E (0.46) | HSP90AA1HSP90AB1LMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704094-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-03-11 | — | — | EP | disclosed |
| US-20250122188-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2025-04-17 | — | — | US | disclosed |
| US-12252640-B2 | Phosphors based on carbene metal complex | CITY UNIVERSITY OF HONG KONG (HK) | 2025-03-18 | — | — | US | disclosed |
| US-20240166652-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2024-05-23 | — | — | US | disclosed |
| EP-4356971-A2 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2024-04-24 | — | — | EP | disclosed |
| CN-115947681-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-04-11 | — | — | CN | disclosed |
| US-20230100202-A1 | PHOSPHORS BASED ON CARBENE METAL COMPLEX | CITY UNIVERSITY OF HONG KONG (HK) | 2023-03-30 | — | — | US | disclosed |
| US-20230098697-A1 | PHOSPHORS BASED ON CARBENE METAL COMPLEX | CITY UNIVERSITY OF HONG KONG (HK) | 2023-03-30 | — | — | US | disclosed |
| US-20230098697-A1 | PHOSPHORS BASED ON CARBENE METAL COMPLEX | CITY UNIVERSITY OF HONG KONG (HK) | 2023-03-30 | — | — | US | disclosed |
| US-20220363678-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-11-17 | — | — | US | disclosed |
| EP-0245230-A1 | Substituted 2,6-substituted pyridine compounds | Monsanto Company (US) | 1987-11-11 | — | — | EP | disclosed |
| US-4698093-A | POST, PRE EMERGENTS | MONSANTO COMPANY (US) | 1987-10-06 | — | — | US | disclosed |
| US-4692184-A | HERBICIDES | MONSANTO COMPANY (US) | 1987-09-08 | — | — | US | disclosed |
| US-4655816-A | PLANT GROWTH REGULATORS | MONSANTO COMPANY (US) | 1987-04-07 | — | — | US | disclosed |
| US-4609399-A | PRE- AND POSTEMERGENCE | MONSANTO COMPANY (US) | 1986-09-02 | — | — | US | disclosed |
| EP-0182769-A1 | 2,6-Substituted pyridine compounds | Monsanto Company (US) | 1986-05-28 | — | — | EP | disclosed |
| EP-0181852-A1 | Substituted 2,6-substituted pyridine compounds | Monsanto Company (US) | 1986-05-21 | — | — | EP | disclosed |
| EP-0181311-A2 | Substituted 4,6-alkoxy pyridinecarboxylate compounds | Monsanto Company (US) | 1986-05-14 | — | — | EP | disclosed |
| EP-0181312-A2 | Process for preparation of substituted pyridines | Monsanto Company (US) | 1986-05-14 | — | — | EP | disclosed |
| EP-0133612-A2 | Substituted 2,6-substituted pyridine compounds | MONSANTO COMPANY (US) | 1985-02-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122188-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | HSP90AA1 249/4885HSP90AB1 158/4885LMNA 3376/4885 |
| US-20240166652-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | HSP90AA1 249/4885HSP90AB1 158/4885LMNA 3376/4885 |
| US-20230100202-A1 | PHOSPHORS BASED ON CARBENE METAL COMPLEX | OCIAD1, OCIAD2, PDCD5 | HSP90AA1 3896/4885HSP90AB1 3950/4885LMNA 4749/4885 |
| US-20220363678-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | HSP90AA1 249/4885HSP90AB1 158/4885LMNA 3376/4885 |
| US-20230098697-A1 | PHOSPHORS BASED ON CARBENE METAL COMPLEX | OCIAD1, OCIAD2, PDCD5 | HSP90AA1 3896/4885HSP90AB1 3950/4885LMNA 4749/4885 |
| US-12252640-B2 | Phosphors based on carbene metal complex | OCIAD1, PDCD5, OCIAD2 | HSP90AA1 3964/4885HSP90AB1 4001/4885LMNA 4771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.