Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.42 |
| ▸ | KLK1 | P06870 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | FURIN | P09958 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1431486 | 1.00 | MASP2 (0.43) | MASP2KLKB1KLK1EPHX2FURIN | |
| SCHEMBL3153048 | 0.93 | KLKB1 (0.49) | MASP2KLKB1KLK1PRCP | |
| SCHEMBL1431700 | 0.93 | KLKB1 (0.49) | MASP2KLKB1KLK1PRCP | |
| SCHEMBL3153403 | 0.88 | MASP2 (0.45) | MASP2EPHX2ROCK2ROCK1F7 | |
| Hydrochloric Acid SCHEMBL1432721 | 0.87 | MASP2 (0.45) | MASP2EPHX2ROCK2ROCK1F7 | |
| Hydrochloric Acid SCHEMBL1432716 | 0.87 | MASP2 (0.45) | MASP2EPHX2ROCK2ROCK1F7 | |
| SCHEMBL1431982 | 0.85 | MASP2 (0.47) | MASP2KLKB1KLK1NFKB1PSMB5 | |
| SCHEMBL3149512 | 0.85 | MASP2 (0.47) | MASP2KLKB1KLK1NFKB1PSMB5 | |
| SCHEMBL3155114 | 0.85 | MAPK14 (0.43) | MASP2KLKB1KLK1 | |
| SCHEMBL1431882 | 0.85 | MAPK14 (0.43) | MASP2KLKB1KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100076015-A1 | Aminopyridine Derivatives | VANTIA LIMITED (GB) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076015-A1 | Aminopyridine Derivatives | CHRM1, ARG1, ARG2 | MASP2 3039/4885KLKB1 3491/4885KLK1 3749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.