Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | CDC42 | P60953 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 5/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21998617 | 0.87 | PRMT5 (0.57) | PRMT5GAACASP6HTR1DHTR1B | |
| SCHEMBL5459664 | 0.84 | GAA (0.70) | PRMT5GAACASP6MAPTALOX15 | |
| SCHEMBL21996536 | 0.82 | GAA (0.67) | PRMT5GAACASP6MAPTALOX15 | |
| SCHEMBL31497434 | 0.81 | ALOX15 (0.52) | PRMT5GAACASP6MAPTALOX15 | |
| SCHEMBL31497423 | 0.79 | MAPT (0.52) | PRMT5GAACASP6MAPTALOX15 | |
| SCHEMBL5447195 | 0.79 | MAPT (0.50) | PRMT5GAACASP6MAPTALOX15 | |
| SCHEMBL21998616 | 0.77 | PRMT5 (0.54) | PRMT5GAACASP6HTR1DHTR1B | |
| SCHEMBL5452010 | 0.77 | PRMT5 (0.60) | PRMT5GAACASP6MAPTALOX15 | |
| SCHEMBL21994103 | 0.77 | CDC42 (0.55) | PRMT5GAACASP6CDC42BRD3 | |
| SCHEMBL12922444 | 0.76 | PRMT5 (0.89) | PRMT5GAACASP6MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119490487-A | Polysubstituted tetrahydrocarbazole compound, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2025-02-21 | — | — | CN | disclosed |