SCHEMBL314999

SCHEMBL314999

Cc1ccc(CC2(N(C)C)CCC(NC(=O)c3ccc(-c4cc(C(F)(F)F)n(C)n4)s3)CC2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.52
GAA P10253 2/20 0.41
POLB P06746 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
HDAC1 Q13547 4/20 0.38
HDAC3 O15379 3/20 0.38
HDAC4 P56524 3/20 0.38
HDAC7 Q8WUI4 3/20 0.38
HDAC2 Q92769 3/20 0.38
HDAC10 Q969S8 3/20 0.38
HDAC11 Q96DB2 3/20 0.38
HDAC8 Q9BY41 3/20 0.38
HDAC6 Q9UBN7 3/20 0.38
HDAC9 Q9UKV0 3/20 0.38
HDAC5 Q9UQL6 3/20 0.38
NCOR2 Q9Y618 2/20 0.38
MAPK11 Q15759 3/20 0.37
MAPK14 Q16539 3/20 0.37
MAPK13 O15264 1/20 0.37
MAPK12 P53778 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL316103 0.93 ALDH1A1 (0.51) ALDH1A1GAAPOLBL3MBTL1HDAC1
SCHEMBL315901 0.93 ALDH1A1 (0.52) ALDH1A1GAAPOLBL3MBTL1HDAC1
SCHEMBL315505 0.88 ALDH1A1 (0.49) ALDH1A1GAAPOLBL3MBTL1AKT1
SCHEMBL316601 0.87 ALDH1A1 (0.49) ALDH1A1GAAPOLBL3MBTL1HDAC1
SCHEMBL316384 0.86 ALDH1A1 (0.49) ALDH1A1GAAPOLBL3MBTL1HDAC1
SCHEMBL316364 0.79 ALDH1A1 (0.44) ALDH1A1GAAPOLBL3MBTL1HDAC1
SCHEMBL1594041 0.78 ALDH1A1 (0.56) ALDH1A1GAAPOLBL3MBTL1HDAC1
SCHEMBL1593688 0.78 ALDH1A1 (0.58) ALDH1A1GAAPOLBL3MBTL1HDAC1
SCHEMBL12589547 0.73 ALDH1A1 (0.55) ALDH1A1GAAPOLBL3MBTL1HDAC1
SCHEMBL2058346 0.73 ALDH1A1 (0.72) ALDH1A1GAAPOLBL3MBTL1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8093272-B2 Heteroaryl substituted cyclohexyl-1,4-diamine compounds GRUENENTHAL GMBH (DE) 2012-01-10 US claimed
US-8093272-B2 Heteroaryl substituted cyclohexyl-1,4-diamine compounds GRUENENTHAL GMBH (DE) 2012-01-10 US disclosed