Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6645597 | 0.84 | STS (0.48) | GPR119 | |
| SCHEMBL12333931 | 0.83 | GPR119 (0.40) | GPR119MAPK1KDM4EPKM | |
| SCHEMBL5705156 | 0.82 | ALDH1A1 (0.44) | KDM4EALDH1A1 | |
| SCHEMBL31503237 | 0.82 | MAPK1 (0.47) | GPR119MAPK1KDM4ENAMPT | |
| SCHEMBL13894673 | 0.80 | JAK2 (0.44) | GPR119MAPK1 | |
| SCHEMBL13894594 | 0.79 | MAPK1 (0.43) | GPR119MAPK1 | |
| SCHEMBL6506074 | 0.79 | SMN1; SMN2 (0.57) | — | |
| SCHEMBL12334050 | 0.79 | TP53 (0.40) | GPR119 | |
| SCHEMBL12406742 | 0.79 | GPR119 (0.44) | GPR119MAPK1 | |
| SCHEMBL12406740 | 0.79 | GPR119 (0.44) | GPR119MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011124525-A1 | COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4 INHIBITORS AND EP4 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-13 | — | — | WO | disclosed |
| WO-2010097334-A1 | DRUG COMBINATIONS CONTAINING PDE4 INHIBITORS AND NSAIDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |