Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 4/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26684723 | 1.00 | LMNA (0.42) | LMNAMAPK14MAP2K3CCNCCDK8 | |
| SCHEMBL26852028 | 0.82 | MAPK14 (0.39) | LMNAMAPK14MAP2K3CCNCCDK8 | |
| SCHEMBL26684326 | 0.73 | CHEK1 (0.44) | LMNAGRM2SIRT6GSK3B | |
| SCHEMBL31507550 | 0.73 | CHEK1 (0.44) | LMNAGRM2SIRT6GSK3B | |
| SCHEMBL30667773 | 0.71 | LMNA (0.40) | LMNAPIM1PIM3PIM2SCN9A | |
| SCHEMBL26863020 | 0.71 | LMNA (0.40) | LMNAPIM1PIM3PIM2SCN9A | |
| SCHEMBL28205638 | 0.69 | MKNK1 (0.49) | MAPK14MAP2K3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11616643 | 0.68 | LMNA (0.59) | LMNAGRM2SIRT6PIM1PIM3 | |
| SCHEMBL30097621 | 0.68 | LMNA (0.59) | LMNAGRM2SIRT6PIM1PIM3 | |
| SCHEMBL23413330 | 0.67 | LMNA (0.57) | LMNAGRM2SIRT6PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119546602-A | Pyrrolidone derivatives as inhibitors of nfkb-induced kinase | 詹森药业有限公司 | 2025-02-28 | — | — | CN | disclosed |