Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 8/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 5/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31507954 | 1.00 | SMPD3 (0.48) | SMPD3LRRK2JAK3MEN1ALDH1A1 | |
| SCHEMBL24092755 | 0.95 | ALDH1A1 (0.45) | SMPD3LRRK2JAK3MEN1ALDH1A1 | |
| SCHEMBL27307882 | 0.80 | SMPD3 (0.42) | SMPD3LRRK2JAK3MEN1ALDH1A1 | |
| SCHEMBL26633307 | 0.79 | SMPD3 (0.50) | SMPD3LRRK2JAK3MEN1ALDH1A1 | |
| SCHEMBL26633305 | 0.79 | SMPD3 (0.50) | SMPD3LRRK2JAK3MEN1ALDH1A1 | |
| SCHEMBL24548234 | 0.79 | CHRNB2 (0.44) | SMPD3LRRK2JAK3MEN1ALDH1A1 | |
| SCHEMBL29739626 | 0.79 | CHRNB2 (0.44) | SMPD3LRRK2JAK3MEN1ALDH1A1 | |
| SCHEMBL24548206 | 0.79 | CHRNB2 (0.44) | SMPD3LRRK2JAK3MEN1ALDH1A1 | |
| SCHEMBL29177381 | 0.79 | CHRNB2 (0.44) | SMPD3LRRK2JAK3MEN1ALDH1A1 | |
| SCHEMBL26633302 | 0.79 | SMPD3 (0.50) | SMPD3LRRK2JAK3MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12384773-B2 | Thiazole compounds and methods of use thereof | ARCUS BIOSCIENCES, INC. (US) | 2025-08-12 | — | — | US | disclosed |
| WO-2025096979-A1 | THIAZOLE COMPOUNDS AS KIT INHIBITORS AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| US-20250145606-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2025-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12384773-B2 | Thiazole compounds and methods of use thereof | TPMT, CYP11B2, ABAT | SMPD3 2484/4885LRRK2 2153/4885JAK3 302/4885 |
| US-20250145606-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | TPMT, CYP11B2, ABAT | SMPD3 2484/4885LRRK2 2153/4885JAK3 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.