SCHEMBL3150865

SCHEMBL3150865

NCC1(COc2cnc(Cl)c(-c3cccc([N+](=O)[O-])c3)c2)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.37
CHRNB1 P11230 1/20 0.37
CHRNB2 P17787 1/20 0.37
CHRNB4 P30926 1/20 0.37
CHRNA3 P32297 1/20 0.37
CHRNB3 Q05901 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
CYP1A2 P05177 1/20 0.35
TDP2 O95551 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
KMT2A Q03164 1/20 0.35
MET P08581 1/20 0.35
IDO1 P14902 1/20 0.35
ADRA2A P08913 3/20 0.35
ADRA2B P18089 3/20 0.35
ADRA2C P18825 3/20 0.35
MGAM O43451 1/20 0.34
GAA P10253 1/20 0.34
SI P14410 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3773705 0.99 MAPT (0.37) MAPTCHRNB1CHRNB2CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL3765945 0.88 LMNA (0.39) MAPTCHRNB4CHRNA3CYP1A2SMN1; SMN2
SCHEMBL3155932 0.84 DHFR (0.39) CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL3767963 0.83 DHFR (0.38) CHRNB4CHRNA3
SCHEMBL3154920 0.83 MAP4K4 (0.35) CHRNB4CHRNA3
SCHEMBL3155946 0.82 FFAR4 (0.41) CHRNB4CHRNA3
SCHEMBL3151836 0.82 CHRNB2 (0.54) MAPTCHRNB1CHRNB2CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL3774060 0.81 FFAR4 (0.40) CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL3781570 0.81 CHRNB2 (0.53) MAPTCHRNB1CHRNB2CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL3775073 0.81 KDM1A (0.36) CHRNB4CHRNA3ADRA2AADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1979321-B9 NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SERVIER LAB (FR) 2010-02-17 EP disclosed
EP-1979321-B1 NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SERVIER LAB (FR) 2009-07-29 EP disclosed