Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11460326 | 0.83 | CHRNB2 (0.37) | DPP4ADRB1SCN4ASCN9AADRB2 | |
| SCHEMBL11460661 | 0.78 | CHRNB2 (0.42) | DPP4HRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL11472212 | 0.73 | CHRNB2 (0.32) | DPP4HRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL3150091 | 0.73 | DPP4 (0.42) | DPP4ADRB1ADRB2KDM4EHRH1 | |
| SCHEMBL4482650 | 0.70 | HRH1 (0.60) | ADRB1KDM4EHRH1USP2SMN1; SMN2 | |
| SCHEMBL3152112 | 0.69 | ADRB1 (0.39) | ADRB1KDM4EHRH1USP2SMN1; SMN2 | |
| SCHEMBL3159834 | 0.69 | ADRB1 (0.40) | ADRB1SCN4ASCN9AKDM4EHRH1 | |
| SCHEMBL4483298 | 0.69 | USP2 (0.61) | KDM4EHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL11479755 | 0.68 | DPP4 (0.39) | DPP4MAPTLMNA | |
| SCHEMBL3152662 | 0.68 | LMNA (0.43) | DPP4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9808456-B2 | Piperazine thiazole derivatives useful in the treatment of tauopathies such as Alzheimer's disease | REMYND NV (BE) | 2017-11-07 | — | — | US | disclosed |
| US-20160101102-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | REMYND NV (BE) | 2016-04-14 | — | — | US | disclosed |
| EP-2744798-B1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | REMYND NV (BE) | 2016-03-30 | — | — | EP | disclosed |
| US-9187440-B2 | Piperazine thiazole derivatives useful in the treatment of tauopathies such as alzheimer's disease | REMYND NV (BE) | 2015-11-17 | — | — | US | disclosed |
| US-20140206699-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | REMYND NV (BE) | 2014-07-24 | — | — | US | disclosed |
| EP-2744798-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | reMynd NV (BE) | 2014-06-25 | — | — | EP | disclosed |
| CN-103649062-A | Piperazine thiazole derivatives useful in the treatment of tauopathies such as alzheimer's disease | REMYND NV | 2014-03-19 | — | — | CN | disclosed |
| WO-2013024168-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | REMYND NV (BE) | 2013-02-21 | — | — | WO | disclosed |
| EP-1765816-B1 | SUBSTITUTED 1-PROPIOLYLPIPERAZINES HAVING AN AFFINITY FOR THE MGLUR5 RECEPTOR IN ORDER TO TREAT PAINFUL CONDITIONS | GRUENENTHAL GMBH (DE) | 2010-03-10 | — | — | EP | disclosed |
| US-7300939-B2 | Substituted 1-propiolylpiperazine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2007-11-27 | — | — | US | disclosed |
| US-20070112011-A1 | Substituted 1-propiolylpiperazine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2007-05-17 | — | — | US | disclosed |
| EP-1765816-A1 | SUBSTITUTED 1-PROPIOLYLPIPERAZINES HAVING AN AFFINITY FOR THE MGLUR5 RECEPTOR IN ORDER TO TREAT PAINFUL CONDITIONS | Grünenthal GmbH (DE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006002981-A1 | SUBSTITUTED 1-PROPIOLYLPIPERAZINES HAVING AN AFFINITY FOR THE MGLUR5 RECEPTOR IN ORDER TO TREAT PAINFUL CONDITIONS | Grünenthal GmbH (DE) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160101102-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | MAPT, PSEN1, RTN3 | DPP4 3894/4885ADRB1 82/4885SCN4A 245/4885 |
| US-20140206699-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | MAPT, PSEN1, RTN3 | DPP4 3894/4885ADRB1 82/4885SCN4A 245/4885 |
| US-20070112011-A1 | Substituted 1-propiolylpiperazine compounds, their preparation and use | GRM5, GRIK5, GRM1 | DPP4 2917/4885ADRB1 310/4885SCN4A 407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.