SCHEMBL31526263

SCHEMBL31526263

COc1ccc(/C=C/c2cn([C@@H]3O[C@H](CSCc4c(C)noc4-c4ccccc4)[C@@H](O)[C@H]3O)c3ncnc(N)c23)cc1

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 6/20 0.42
▸ METTL3 Q86U44 3/20 0.42
▸ ADK P55263 7/20 0.40
▸ DOT1L Q8TEK3 4/20 0.40
▸ NNMT P40261 2/20 0.40
▸ PRMT3 O60678 2/20 0.40
▸ DNMT1 P26358 2/20 0.40
▸ NADK O95544 1/20 0.40
▸ GNMT Q14749 1/20 0.40
▸ PRMT9 Q6P2P2 1/20 0.39
▸ EHMT2 Q96KQ7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31526176 0.94 ADK (0.44) PRMT5METTL3ADKDOT1LNNMT
SCHEMBL31526145 0.88 PRMT5 (0.32) PRMT5METTL3ADKNNMTPRMT9
SCHEMBL31526270 0.87 ADK (0.45) PRMT5METTL3ADKDOT1LNNMT
SCHEMBL31526186 0.84 ADK (0.58) PRMT5ADKDOT1LNNMTPRMT3
SCHEMBL31570710 0.83 ADK (0.47) PRMT5ADKDOT1LNNMTPRMT3
SCHEMBL31526255 0.83 ADK (0.56) PRMT5ADKDOT1LNNMTPRMT3
SCHEMBL31526383 0.83 DOT1L (0.47) PRMT5ADKDOT1LNNMTPRMT3
SCHEMBL31526392 0.83 ADK (0.49) PRMT5ADKDOT1LNNMTPRMT3
SCHEMBL31526089 0.81 ADK (0.45) PRMT5METTL3ADKDOT1LNNMT
SCHEMBL31526342 0.81 ADK (0.55) PRMT5ADKDOT1LNNMTPRMT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025098545-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I. (CZ) 2025-05-15 — — WO disclosed
EP-4553080-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES Ustav Organicke Chemie a Biochemie AV CR, v.v.i. (CZ) 2025-05-14 — — EP disclosed
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