SCHEMBL31526145

SCHEMBL31526145

COc1ccc(/C=C/c2cn([C@@H]3O[C@H](CSCc4c(C)noc4-c4ccccc4)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]3O[Si](C)(C)C(C)(C)C)c3ncnc(N)c23)cc1

nearest known ligand 0.32

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 3/20 0.32
▸ METTL3 Q86U44 1/20 0.32
▸ PRMT9 Q6P2P2 1/20 0.31
▸ RIPK2 O43353 2/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ UBE2N P61088 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ ADK P55263 1/20 0.31
▸ EGFR P00533 2/20 0.30
▸ ABL1 P00519 1/20 0.30
▸ SRC P12931 1/20 0.30
▸ KDR P35968 1/20 0.30
▸ ABL2 P42684 1/20 0.30
▸ NNMT P40261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31526178 0.95 PRMT5 (0.33) PRMT5METTL3PRMT9ADKNNMT
SCHEMBL31526198 0.89 PRMT5 (0.34) PRMT5METTL3PRMT9ADKNNMT
SCHEMBL31526263 0.88 PRMT5 (0.42) PRMT5METTL3PRMT9ADKNNMT
SCHEMBL31526181 0.85 ADK (0.41) PRMT5PRMT9ADKNNMT
SCHEMBL31526088 0.85 ADK (0.36) PRMT5METTL3PRMT9KDM4EADK
SCHEMBL31526233 0.84 DOT1L (0.43) PRMT5PRMT9ADK
SCHEMBL31526221 0.84 PRMT5 (0.34) PRMT5PRMT9ADKNNMT
SCHEMBL31526395 0.83 PRMT5 (0.35) PRMT5METTL3PRMT9KDM4EADK
SCHEMBL31526128 0.83 ADK (0.33) PRMT5PRMT9ADKNNMT
SCHEMBL31526151 0.83 PRMT5 (0.35) PRMT5PRMT9ADKNNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025098545-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I. (CZ) 2025-05-15 — — WO disclosed
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