Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.69 |
| ▸ | HTT | P42858 | 5/20 | 0.69 |
| ▸ | NPM1 | P06748 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | CNR2 | P34972 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | SNCA | P37840 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28602068 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HTTNPM1POLB | |
| SCHEMBL29377589 | 0.84 | ALDH1A1 (0.78) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL1418988 | 0.84 | ALDH1A1 (0.78) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL8758318 | 0.83 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2HTTPOLBKMT2A | |
| SCHEMBL29503950 | 0.83 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL4363978 | 0.83 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL17943665 | 0.83 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HTTNPM1POLB | |
| SCHEMBL8686788 | 0.83 | APP (0.55) | ALDH1A1SMN1; SMN2HTTNPM1POLB | |
| SCHEMBL4363865 | 0.82 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL15471742 | 0.82 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304421-B2 | Indole compounds and their use as radiation sensitizing agents and chemotherapeutic agents | VANDERBILT UNIVERSITY (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100081678-A1 | INDOLE COMPOUNDS AND THEIR USE AS RADIATION SENSITIZING AGENTS AND CHEMOTHERAPEUTIC AGENTS | VANDERBILT UNIVERSITY | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081678-A1 | INDOLE COMPOUNDS AND THEIR USE AS RADIATION SENSITIZING AGENTS AND CHEMOTHERAPEUTIC AGENTS | IDO1, IDO2, INMT | ALDH1A1 599/4885SMN1; SMN2 4678/4885HTT 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.