Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.55 |
| ▸ | SNCA | P37840 | 2/20 | 0.51 |
| ▸ | NPM1 | P06748 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8687577 | 0.87 | APP (0.53) | APPSNCANPM1HTTALDH1A1 | |
| SCHEMBL6192299 | 0.83 | ALDH1A1 (0.51) | APPSNCAPOLBHTTALDH1A1 | |
| SCHEMBL8394619 | 0.83 | APP (0.63) | APPSNCASLC2A1HTTALDH1A1 | |
| SCHEMBL3153751 | 0.83 | ALDH1A1 (0.69) | APPSNCANPM1POLBHTT | |
| SCHEMBL8685269 | 0.82 | SMN1; SMN2 (0.50) | APPSNCAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL31668340 | 0.82 | ALDH1A1 (0.68) | APPSNCAPOLBHTTALDH1A1 | |
| SCHEMBL8685406 | 0.80 | APP (0.49) | APPSNCAPOLBHTTALDH1A1 | |
| SCHEMBL13557315 | 0.79 | POLB (0.51) | APPSNCAPOLBHTTALDH1A1 | |
| SCHEMBL8685588 | 0.79 | GCGR (0.54) | APPSNCAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL8810593 | 0.78 | PARP1 (0.57) | APPSNCANPM1DHFRSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |