Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.52 |
| ▸ | DRD3 | P35462 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | CCR2 | P41597 | 9/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3153470 | 0.93 | CCR2 (0.50) | HTR1ADRD3HTR2ACCR2DRD4 | |
| SCHEMBL3150162 | 0.89 | CCR2 (0.56) | HTR1ADRD3HTR2ACCR2ALDH1A1 | |
| SCHEMBL3148937 | 0.89 | DRD4 (0.51) | DRD3CCR2DRD4DRD2SMN1; SMN2 | |
| SCHEMBL3154547 | 0.87 | DRD4 (0.54) | HTR1ADRD3CCR2DRD4DRD2 | |
| SCHEMBL3149584 | 0.86 | CCR2 (0.50) | DRD3CCR2DRD4DRD2SMN1; SMN2 | |
| SCHEMBL3139591 | 0.85 | CCR2 (0.52) | HTR1ADRD3HTR2ACCR2ALDH1A1 | |
| SCHEMBL3145416 | 0.83 | DRD4 (0.52) | HTR1ADRD3CCR2DRD4SMN1; SMN2 | |
| SCHEMBL3145283 | 0.81 | CCR2 (0.49) | CCR2MCHR1 | |
| SCHEMBL3153343 | 0.81 | DRD2 (0.54) | DRD3DRD4DRD2ALDH1A1 | |
| SCHEMBL3139271 | 0.80 | DRD4 (0.52) | DRD3CCR2DRD4DRD2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074083-B1 | NEW SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2013-06-19 | — | — | EP | disclosed |
| US-20100075978-A1 | SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT. (HU) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075978-A1 | SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | BDKRB1, BDKRB2, TRPV1 | HTR1A 709/4885DRD3 467/4885HTR2A 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.