SCHEMBL31556549

SCHEMBL31556549

CC(C)(C)OC(=O)N1CCCC(C#Cc2cccc(C(F)(F)F)c2)C1

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ USP30 Q70CQ3 2/20 0.43
▸ MAPT P10636 2/20 0.42
▸ TACR1 P25103 1/20 0.41
▸ GRM5 P41594 2/20 0.41
▸ KMT2A Q03164 2/20 0.41
▸ GPR119 Q8TDV5 2/20 0.40
▸ STS P08842 1/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ POLB P06746 2/20 0.39
▸ LMNA P02545 1/20 0.39
▸ HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30836036 1.00 USP30 (0.43) USP30MAPTTACR1GRM5KMT2A
SCHEMBL31556508 0.94 TACR1 (0.44) USP30MAPTTACR1GRM5KMT2A
SCHEMBL30835966 0.94 TACR1 (0.44) USP30MAPTTACR1GRM5KMT2A
SCHEMBL30835997 0.88 GPR119 (0.47) MAPTGRM5GPR119STSPOLB
SCHEMBL27400097 0.82 TEAD1 (0.52) POLB
SCHEMBL30835993 0.81 GPR119 (0.48) USP30MAPTTACR1GPR119STS
SCHEMBL193960 0.81 MEN1 (0.45) USP30MAPTKMT2AGPR119MEN1
SCHEMBL30028494 0.76 USP30 (0.52) USP30MAPTKMT2AGPR119MEN1
SCHEMBL24781306 0.76 KMT2A (0.59) USP30MAPTKMT2A
SCHEMBL30028550 0.76 KMT2A (0.59) USP30MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119894866-A YAP/TAZ-TEAD oncoprotein inhibitors 布里奇恩生物科学公司 2025-04-25 — — CN disclosed
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