Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 8/20 | 0.59 |
| ▸ | HTR2C known ✓ | P28335 | 8/20 | 0.59 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 4/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25307027 | 0.90 | HTR2A (0.71) | HTR2AHTR2CP2RX7HDAC1HDAC6 | |
| SCHEMBL30515247 | 0.90 | HTR2A (0.71) | HTR2AHTR2CP2RX7HDAC1HDAC6 | |
| Fumaric Acid SCHEMBL23927817 | 0.88 | HTR2C (0.77) | HTR2AHTR2CP2RX7HTR1DCYP1A2 | |
| Fumaric Acid SCHEMBL31561802 | 0.87 | HTR2A (0.42) | HTR2AHTR2CP2RX7SCN9A | |
| Fumaric Acid SCHEMBL31561804 | 0.87 | HTR7 (0.44) | HTR2AHTR2CP2RX7HTR1DKMO | |
| Fumaric Acid SCHEMBL31561794 | 0.87 | HTR2A (0.54) | HTR2AHTR2CP2RX7HDAC1HDAC6 | |
| SCHEMBL25310229 | 0.76 | HTR7 (0.51) | HTR2AHTR2CP2RX7HTR1DSCN9A | |
| SCHEMBL25310205 | 0.76 | HTR2A (0.50) | HTR2AHTR2CP2RX7SCN9A | |
| SCHEMBL30515272 | 0.76 | HTR2A (0.50) | HTR2AHTR2CP2RX7SCN9A | |
| SCHEMBL25309823 | 0.76 | HTR2A (0.64) | HTR2AHTR2CP2RX7HTR1DNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250136548-A1 | FUNCTIONALIZED ALKYLAMINES | TERRAN BIOSCIENCES INC (US) | 2025-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250136548-A1 | FUNCTIONALIZED ALKYLAMINES | BDNF, HTR2A, NTRK2 | HTR2A 2/4885HTR2C 6/4885HTR2B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.