Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361435 | 0.82 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL3152340 | 0.78 | ALDH1A1 (0.42) | KDM4EALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL14895637 | 0.76 | MAPK1 (0.47) | KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL69400 | 0.76 | SMN1; SMN2 (0.60) | KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL7473643 | 0.73 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL1829222 | 0.73 | SIRT2 (0.47) | KDM4EALDH1A1SMN1; SMN2MAPTKCNN4 | |
| SCHEMBL20488594 | 0.72 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP1A2POLBRAB9AMAPT | |
| SCHEMBL687803 | 0.72 | NOTUM (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDPOLB | |
| SCHEMBL24798624 | 0.71 | BRD4 (0.64) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL23185750 | 0.71 | BRD4 (0.64) | KDM4EALDH1A1HSD17B10HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099452-B1 | TRICARBONYL COMPLEXES WITH TRIDENTATE CHELATORS FOR MYOCARDIUM IMAGING | MALLINCKRODT LLC (US) | 2015-07-22 | — | — | EP | disclosed |
| US-9023315-B2 | Tricarbonyl complexes with tridentate chelators for myocardium imaging | MALLINCKRODT LLC (US) | 2015-05-05 | — | — | US | disclosed |
| US-8940273-B2 | Tricarbonyl complexes with tridentate chelators for myocardium imaging | MALLINCKRODT LLC (US) | 2015-01-27 | — | — | US | disclosed |
| US-20130131327-A1 | Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | MALLINCKRODT LLC (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130129620-A1 | Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | MALLINCKRODT LLC (US) | 2013-05-23 | — | — | US | disclosed |
| US-8372379-B2 | Technetium-99m (I) tricarbonyl complexes with tridentate chelators for myocardium imaging | MALLINCKRODT LLC (US) | 2013-02-12 | — | — | US | disclosed |
| US-20100074842-A1 | Technetium-99m (I) Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | LIEBEL-FLARSHEIM COMPANY LLC | 2010-03-25 | — | — | US | disclosed |
| EP-2099452-A2 | TRICARBONYL COMPLEXES WITH TRIDENTATE CHELATORS FOR MYOCARDIUM IMAGING | Mallinckrodt Inc. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008061792-A2 | TRICARBONYL COMPLEXES WITH TRIDENTATE CHELATORS FOR MYOCARDIUM IMAGING | MALLINCKRODT INC. (US) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131327-A1 | Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | TNNT2, TNNI3, FABP3 | KDM4E 1256/4885ALDH1A1 3518/4885SMN1; SMN2 4063/4885 |
| US-20100074842-A1 | Technetium-99m (I) Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | TNNT2, TNNI3, FABP3 | KDM4E 1564/4885ALDH1A1 3726/4885SMN1; SMN2 4228/4885 |
| US-20130129620-A1 | Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging | TNNT2, TNNI3, FABP3 | KDM4E 1256/4885ALDH1A1 3518/4885SMN1; SMN2 4063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.