Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 3/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14010827 | 0.92 | KDM4E (0.61) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL7456549 | 0.89 | KDM4E (0.68) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL7453112 | 0.87 | KDM4E (0.65) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL14227941 | 0.82 | KDM4E (0.57) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL1875159 | 0.81 | KDM4E (0.80) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| Famciclovir SCHEMBL8190642 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| Famciclovir SCHEMBL29357294 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL7816738 | 0.80 | KDM4E (0.56) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL13645718 | 0.80 | HSP90AB1 (0.51) | HDAC6HSP90AA1HSP90AB1CYP2C19 | |
| Famciclovir SCHEMBL2949 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HPGDADRA1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883639-B1 | PREPARATION OF FAMCICLOVIR AND OTHER PURINE DERIVATIVES | ARROW INT LTD (MT) | 2010-09-01 | — | — | EP | disclosed |
| EP-1636231-B1 | METHODS FOR PREPARING 9-[4-ACETOXY-3-(ACETOXYMETHYL)BUT-1-YL]-2-AMINOPURINE USING A COMPOUND OF 2-AMINO-9-(2-SUBSTITUTED ETHYL)PURINES | KYUNGDONG PHARM CO LTD (KR) | 2010-03-24 | — | — | EP | disclosed |
| US-7601835-B2 | Preparation of famciclovir and other purine derivatives | ARROW INTERNATIONAL LIMITED (MT) | 2009-10-13 | — | — | US | disclosed |
| US-7601835-B2 | Preparation of famciclovir and other purine derivatives | ARROW INTERNATIONAL LIMITED (MT) | 2009-10-13 | — | — | US | disclosed |
| CN-100455583-C | 2-amino-9- (2-substituted ethyl) purines and methods of using same to prepare 9- [ 4-acetoxy-3- (acetoxymethyl) butan-1-yl ] -2-aminopurine | KYUNGDONG PHARM CO LTD (KR) | 2009-01-28 | — | — | CN | disclosed |
| US-7456282-B2 | 2-amino-9-(2-substituted ethyl)purines and preparing methods for 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine using the same | KYUNGDONG PHARM. CO., LTD. (KR) | 2008-11-25 | — | — | US | disclosed |
| US-7456282-B2 | 2-amino-9-(2-substituted ethyl)purines and preparing methods for 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine using the same | KYUNGDONG PHARM. CO., LTD. (KR) | 2008-11-25 | — | — | US | disclosed |
| US-7456282-B2 | 2-amino-9-(2-substituted ethyl)purines and preparing methods for 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine using the same | KYUNGDONG PHARM. CO., LTD. (KR) | 2008-11-25 | — | — | US | disclosed |
| US-7355043-B2 | Preparation of purines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2008-04-08 | — | — | US | disclosed |
| US-20060258862-A1 | 2-Amino-9-(2-substituted ethyl)purines and preparing methods for 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine using the same | KYUNGDONG PHARM. CO., LTD. (KR) | 2006-11-16 | — | — | US | disclosed |
| CN-1791602-A | 2-amino-9-(2-substituted ethyl)purines and preparing methods for 9- 4-acetoxy-3-(acetoxymethyl)but-1-yl]- 2- aminopurine using the same | KYUNGDONG PHARM CO LTD (KR) | 2006-06-21 | — | — | CN | disclosed |
| EP-1636231-A2 | 2-AMINO-9-(2-SUBSTITUTED ETHYL)PURINES AND PREPARING METHODS FOR 9- 4-ACETOXY-3-(ACETOXYMETHYL)BUT-1-YL]- 2- AMINOPURINE USING THE SAME | Kyungdong Pharm. Co., Ltd. (KR) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004110343-A2 | 2-AMINO-9-(2-SUBSTITUTED ETHYL)PURINES AND PREPARING METHODS FOR 9-[4-ACETOXY-3-(ACETOXYMETHYL)BUT-1-YL]- 2- AMINOPURINE USING THE SAME | KYUNGDONG PHARM. CO., LTD. (KR) | 2004-12-23 | — | — | WO | disclosed |
| EP-0916674-B1 | Purine derivatives having cyclopropane ring | SUMIKA FINE CHEMICALS CO LTD (JP) | 2002-05-08 | — | — | EP | disclosed |
| US-6342603-B1 | PREPARING CYCLOPROPANE RING-CLEAVED PURINE DERIVATIVE BY HYDROGENATING PURINE DERIVATIVE HAVING CYCLOPROPANE RING | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-01-29 | — | — | US | disclosed |
| US-6156892-A | Purine derivatives having cyclopropane ring | SUMIKA FIRE CHEMICALS CO., LTD. (JP) | 2000-12-05 | — | — | US | disclosed |
| EP-0916674-A1 | Purine derivatives having cyclopropane ring | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| EP-0302644-B1 | Purine compounds and their preparation | BEECHAM GROUP PLC (GB) | 1997-01-29 | — | — | EP | disclosed |
| US-5175288-A | Process for preparing purine derivatives and intermediates thereof | BEECHAM GROUP P.L.C. (GB) | 1992-12-29 | — | — | US | disclosed |
| EP-0302644-A2 | Purine compounds and their preparation | BEECHAM GROUP PLC (GB) | 1989-02-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258862-A1 | 2-Amino-9-(2-substituted ethyl)purines and preparing methods for 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine using the same | TYMP, TPMT, PNP | KDM4E 783/4885ALDH1A1 1015/4885HPGD 2021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.