Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 5/20 | 0.35 |
| ▸ | EP300 | Q09472 | 3/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14227940 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL6153979 | 0.81 | HSP90AB1 (0.50) | HDAC6HSP90AA1HSP90AB1CYP2C19 | |
| SCHEMBL3156963 | 0.80 | KDM4E (0.67) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL7813344 | 0.80 | CYP2C19 (0.46) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL9115124 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL9115848 | 0.77 | KDM4E (0.63) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL6770698 | 0.76 | HSP90AB1 (0.48) | HDAC6HSP90AA1HSP90AB1CYP2C19 | |
| SCHEMBL9116325 | 0.76 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL14010827 | 0.76 | KDM4E (0.61) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL14010824 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1HPGDADRA1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7355043-B2 | Preparation of purines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2008-04-08 | — | — | US | disclosed |
| EP-0352953-B1 | Process for the preparation of purine derivatives | BEECHAM GROUP PLC (GB) | 2001-01-03 | — | — | EP | disclosed |
| EP-0302644-B1 | Purine compounds and their preparation | BEECHAM GROUP PLC (GB) | 1997-01-29 | — | — | EP | disclosed |
| US-5175288-A | Process for preparing purine derivatives and intermediates thereof | BEECHAM GROUP P.L.C. (GB) | 1992-12-29 | — | — | US | disclosed |
| US-5017701-A | Process for the preparation of purine derivatives | BEECHAM GROUP, P.L.C. (GB) | 1991-05-21 | — | — | US | disclosed |
| EP-0352953-A2 | Process for the preparation of purine derivatives | BEECHAM GROUP PLC (GB) | 1990-01-31 | — | — | EP | disclosed |
| EP-0302644-A2 | Purine compounds and their preparation | BEECHAM GROUP PLC (GB) | 1989-02-08 | — | — | EP | disclosed |