Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 14/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28634875 | 0.85 | MAPT (0.52) | DRD4LMNAMAPT | |
| SCHEMBL31569825 | 0.82 | KCNH2 (0.57) | BACE1KCNH2LMNAMAPTPDE3B | |
| SCHEMBL23964227 | 0.81 | LMNA (0.53) | TBK1BACE1DRD4LMNA | |
| SCHEMBL23932558 | 0.80 | RPS6KB1 (0.55) | TBK1KCNH2 | |
| SCHEMBL31569805 | 0.78 | DDB1 (0.56) | TBK1PDE3BPDE3A | |
| SCHEMBL12026566 | 0.78 | MAPT (0.47) | LMNAMAPT | |
| SCHEMBL31569998 | 0.77 | KMT2A (0.56) | LMNA | |
| SCHEMBL31569643 | 0.77 | PIK3CA (0.44) | TBK1BACE1IKBKE | |
| SCHEMBL2325142 | 0.77 | HTT (0.62) | DRD2DRD4MAPT | |
| SCHEMBL8126555 | 0.76 | VEGFA (0.46) | TBK1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025101588-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2025-05-15 | — | — | WO | disclosed |