Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31599171 | 0.85 | L3MBTL1 (0.46) | PARP1HDAC8HDAC6HPGDTDP1 | |
| SCHEMBL27582425 | 0.82 | PARP1 (0.59) | PARP1HDAC8HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL6932732 | 0.80 | PARP1 (0.57) | PARP1HDAC8HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL851367 | 0.77 | CNR2 (0.51) | HDAC8SMN1; SMN2TDP1POLB | |
| SCHEMBL186545 | 0.76 | PARP1 (0.68) | PARP1HDAC8HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL29503529 | 0.76 | PARP1 (0.68) | PARP1HDAC8HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL3753879 | 0.76 | PARP1 (0.68) | PARP1HDAC8HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL11047948 | 0.76 | HDAC8 (0.58) | PARP1HDAC8HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL11547505 | 0.76 | PARP1 (0.57) | PARP1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL30725451 | 0.76 | PARP1 (0.57) | PARP1SMN1; SMN2MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455590-B2 | Modified triaroylbenzene-skeleton polymer | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-06-04 | — | — | US | disclosed |
| US-8455590-B2 | Modified triaroylbenzene-skeleton polymer | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-06-04 | — | — | US | disclosed |
| US-20110319551-A1 | MODIFIED TRIAROYLBENZENE-SKELETON POLYMER | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-12-29 | — | — | US | disclosed |
| US-20110319551-A1 | MODIFIED TRIAROYLBENZENE-SKELETON POLYMER | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-12-29 | — | — | US | disclosed |
| EP-1753719-B1 | SUBSTITUTED PYRROLIDINE-2-ONES | NOVARTIS AG (CH) | 2010-03-03 | — | — | EP | disclosed |
| US-20070172421-A1 | Substituted pyrrolidine-2-ones | NOVARTIS AG (CH) | 2007-07-26 | — | — | US | disclosed |
| EP-1753719-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | Novartis AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005118535-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | NOVARTIS AG (CH) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319551-A1 | MODIFIED TRIAROYLBENZENE-SKELETON POLYMER | F12, FLNB, F3 | PARP1 2258/4885HDAC8 3954/4885HDAC6 2257/4885 |
| US-20070172421-A1 | Substituted pyrrolidine-2-ones | PRLHR, EPOR, FLT1 | PARP1 152/4885HDAC8 4812/4885HDAC6 2679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.