Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 5/20 | 0.36 |
| ▸ | BCR | P11274 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24944444 | 0.84 | ABL1 (0.37) | AXLABL1BCRKDM4EKDR | |
| SCHEMBL29173374 | 0.84 | ABL1 (0.37) | AXLABL1BCRKDM4EKDR | |
| SCHEMBL30206314 | 0.84 | ABL1 (0.37) | AXLABL1BCRKDM4EKDR | |
| SCHEMBL31577202 | 0.82 | CDK1 (0.37) | AXLKDR | |
| Formic Acid SCHEMBL29173306 | 0.82 | ABL1 (0.36) | AXLABL1BCRKDM4EKDR | |
| Formic Acid SCHEMBL30205502 | 0.82 | ABL1 (0.36) | AXLABL1BCRKDM4EKDR | |
| SCHEMBL31577227 | 0.78 | JAK2 (0.36) | EGFR | |
| SCHEMBL31577218 | 0.78 | CCNA2 (0.35) | AXL | |
| SCHEMBL31577243 | 0.78 | CCNA2 (0.35) | AXL | |
| SCHEMBL31577223 | 0.78 | MC4R (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | claimed |