Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 5/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | IL6 | P05231 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 4/20 | 0.33 |
| ▸ | CCNC | P24863 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31577208 | 0.88 | HRH3 (0.33) | FLT3PDCD1CD274TLR7AXL | |
| SCHEMBL31577264 | 0.88 | HRH3 (0.33) | FLT3PDCD1CD274TLR7AXL | |
| SCHEMBL31577243 | 0.88 | CCNA2 (0.35) | CDK1FLT3AXL | |
| SCHEMBL31577218 | 0.88 | CCNA2 (0.35) | CDK1FLT3AXL | |
| SCHEMBL31577233 | 0.88 | CCNC (0.36) | MELKTLR7CCNCCDK8PDGFRA | |
| SCHEMBL31577228 | 0.82 | AXL (0.37) | KDRAXL | |
| SCHEMBL24944172 | 0.82 | TBK1 (0.39) | CDK1KDRFLT3MELKAXL | |
| SCHEMBL31577217 | 0.82 | FLT3 (0.33) | FLT3AXLCCNCCDK8PDGFRA | |
| SCHEMBL29173404 | 0.81 | MAPK10 (0.40) | KDR | |
| Formic Acid SCHEMBL30205666 | 0.80 | TBK1 (0.37) | CDK1KDRFLT3MELKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | claimed |