Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.33 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 10/20 | 0.32 |
| ▸ | CLK3 | P49761 | 10/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.32 |
| ▸ | WNT1 | P04628 | 3/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31577202 | 0.88 | CDK1 (0.37) | CCNCCDK8TLR7MELKPDGFRA | |
| SCHEMBL31577264 | 0.85 | HRH3 (0.33) | TLR7PDGFRA | |
| SCHEMBL31577208 | 0.85 | HRH3 (0.33) | TLR7PDGFRA | |
| SCHEMBL24944427 | 0.84 | CCNC (0.38) | CCNCCDK8TLR7MELKCLK2 | |
| SCHEMBL31577218 | 0.82 | CCNA2 (0.35) | — | |
| SCHEMBL31577243 | 0.82 | CCNA2 (0.35) | — | |
| Formic Acid SCHEMBL29173318 | 0.82 | CCNC (0.38) | CCNCCDK8TLR7MELKCLK2 | |
| Formic Acid SCHEMBL30205548 | 0.82 | CCNC (0.38) | CCNCCDK8TLR7MELKCLK2 | |
| SCHEMBL29173642 | 0.77 | SYK (0.38) | — | |
| SCHEMBL29173404 | 0.76 | MAPK10 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | claimed |