Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 8/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31577208 | 1.00 | HRH3 (0.33) | HRH3FLT3CHEK1TLR7AXL | |
| SCHEMBL31577202 | 0.88 | CDK1 (0.37) | FLT3CHEK1TLR7AXLPDCD1 | |
| SCHEMBL31577243 | 0.88 | CCNA2 (0.35) | FLT3AXL | |
| SCHEMBL31577218 | 0.88 | CCNA2 (0.35) | FLT3AXL | |
| SCHEMBL31577233 | 0.85 | CCNC (0.36) | TLR7PDGFRA | |
| SCHEMBL24944446 | 0.84 | EML4 (0.36) | FLT3PDGFRA | |
| SCHEMBL24944169 | 0.84 | EML4 (0.36) | FLT3PDGFRA | |
| SCHEMBL24944443 | 0.84 | EML4 (0.36) | FLT3PDGFRA | |
| Formic Acid SCHEMBL30205526 | 0.82 | EML4 (0.34) | FLT3PDGFRA | |
| Formic Acid SCHEMBL29173283 | 0.82 | EML4 (0.34) | FLT3PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | claimed |