Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 3/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | CLK3 | P49761 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 4/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL30205548 | 0.97 | CCNC (0.38) | CCNCCDK8GRM2MELKIKBKE | |
| Formic Acid SCHEMBL29173318 | 0.97 | CCNC (0.38) | CCNCCDK8GRM2MELKIKBKE | |
| SCHEMBL24944172 | 0.89 | TBK1 (0.39) | CCNCCDK8MELKIKBKETBK1 | |
| SCHEMBL24943840 | 0.88 | IKBKE (0.46) | MELKIKBKETBK1SYKEML4 | |
| SCHEMBL30205589 | 0.88 | IKBKE (0.46) | MELKIKBKETBK1SYKEML4 | |
| SCHEMBL24944183 | 0.87 | SYK (0.44) | CCNCCDK8SYKPDGFRAEML4 | |
| SCHEMBL30205579 | 0.87 | SYK (0.44) | CCNCCDK8SYKPDGFRAEML4 | |
| SCHEMBL30801879 | 0.86 | IKBKE (0.35) | CCNCCDK8IKBKETBK1SYK | |
| SCHEMBL24944188 | 0.86 | IKBKE (0.35) | CCNCCDK8IKBKETBK1SYK | |
| SCHEMBL24944443 | 0.86 | EML4 (0.36) | GRM2IKBKETBK1SYKPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |