Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31577350 | 0.84 | AOC3 (0.37) | LRRK2AOC3 | |
| SCHEMBL29173386 | 0.81 | LRRK2 (0.43) | LRRK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL30206109 | 0.81 | LRRK2 (0.43) | LRRK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL31577363 | 0.75 | AOC3 (0.37) | AOC3TYK2 | |
| SCHEMBL29173398 | 0.74 | LRRK2 (0.40) | LRRK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL30206021 | 0.74 | LRRK2 (0.40) | LRRK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL30206025 | 0.74 | ALK (0.36) | LRRK2TGFBR1CHEK1EGFRCDK1 | |
| SCHEMBL29173326 | 0.74 | ALK (0.36) | LRRK2TGFBR1CHEK1EGFRCDK1 | |
| SCHEMBL31577281 | 0.74 | RPS6KA5 (0.41) | JAK2JAK3 | |
| SCHEMBL24944783 | 0.74 | LRRK2 (0.41) | LRRK2JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |