Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31577281 | 0.90 | RPS6KA5 (0.41) | RPS6KA5ATMMEN1KMT2APOLB | |
| SCHEMBL31577326 | 0.81 | RPS6KA5 (0.37) | RPS6KA5ATMMEN1KMT2APOLB | |
| SCHEMBL31577339 | 0.78 | BMI1 (0.37) | MEN1KMT2APOLBGSK3BCHEK2 | |
| SCHEMBL31577323 | 0.77 | NAMPT (0.30) | BMPR2NAMPTCHEK2TYK2 | |
| SCHEMBL31577359 | 0.76 | BUB1 (0.33) | — | |
| SCHEMBL31577363 | 0.72 | AOC3 (0.37) | TYK2 | |
| SCHEMBL18691789 | 0.71 | TP53 (0.39) | ATMMEN1KMT2AGSK3BSMN1; SMN2 | |
| SCHEMBL29173737 | 0.70 | IKBKB (0.32) | — | |
| SCHEMBL31577393 | 0.69 | TP53 (0.31) | POLBTP53 | |
| SCHEMBL25080568 | 0.65 | KDM4E (0.41) | ATMMEN1KMT2ASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |