Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29173495 | 0.79 | — | — | |
| SCHEMBL30205931 | 0.79 | — | — | |
| SCHEMBL31577281 | 0.77 | RPS6KA5 (0.41) | TP53POLB | |
| SCHEMBL31577339 | 0.76 | BMI1 (0.37) | POLB | |
| SCHEMBL31577303 | 0.75 | JAK2 (0.32) | TP53 | |
| SCHEMBL31577344 | 0.75 | BRD4 (0.30) | — | |
| SCHEMBL31577350 | 0.71 | AOC3 (0.37) | AOC3 | |
| SCHEMBL31577284 | 0.70 | LRRK2 (0.41) | AOC3 | |
| SCHEMBL31577293 | 0.69 | RPS6KA5 (0.41) | TP53POLB | |
| SCHEMBL31577359 | 0.68 | BUB1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |