Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMI1 | P35226 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 6/20 | 0.34 |
| ▸ | JAK1 | P23458 | 6/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31577323 | 0.79 | NAMPT (0.30) | TYK2CHEK2 | |
| SCHEMBL31577359 | 0.78 | BUB1 (0.33) | — | |
| SCHEMBL31577293 | 0.78 | RPS6KA5 (0.41) | KDM4EMEN1POLBKMT2ATDP1 | |
| SCHEMBL24944459 | 0.78 | JAK3 (0.35) | MEN1KMT2AJAK2JAK1GSK3A | |
| SCHEMBL31577393 | 0.76 | TP53 (0.31) | POLB | |
| SCHEMBL31577281 | 0.73 | RPS6KA5 (0.41) | KDM4EMEN1POLBKMT2AJAK2 | |
| SCHEMBL31577326 | 0.71 | RPS6KA5 (0.37) | KDM4EMEN1POLBKMT2ATDP1 | |
| SCHEMBL31577363 | 0.71 | AOC3 (0.37) | TYK2KCNH2 | |
| SCHEMBL24944970 | 0.71 | LCK (0.40) | MAPK1JAK3PLK1BCDIN3DLCK | |
| SCHEMBL31577344 | 0.70 | BRD4 (0.30) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |