Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.30 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31577339 | 0.79 | BMI1 (0.37) | TYK2CHEK2 | |
| SCHEMBL24944480 | 0.78 | TYK2 (0.31) | TYK2 | |
| SCHEMBL30206301 | 0.78 | TYK2 (0.31) | TYK2 | |
| SCHEMBL31577293 | 0.77 | RPS6KA5 (0.41) | NAMPTBMPR2TYK2CHEK2 | |
| SCHEMBL31577303 | 0.75 | JAK2 (0.32) | NAMPT | |
| SCHEMBL31577359 | 0.73 | BUB1 (0.33) | — | |
| SCHEMBL31577281 | 0.71 | RPS6KA5 (0.41) | — | |
| SCHEMBL31577326 | 0.71 | RPS6KA5 (0.37) | NAMPTBMPR2CHEK2 | |
| SCHEMBL31577363 | 0.69 | AOC3 (0.37) | TYK2EML4ALK | |
| SCHEMBL24944982 | 0.68 | TYK2 (0.37) | TYK2EML4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |