Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.61 |
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28745022 | 0.77 | MEN1 (0.49) | MEN1KMT2AMAPTRAB9AL3MBTL1 | |
| SCHEMBL145274 | 0.76 | MEN1 (0.68) | MEN1KMT2AMAPTRAB9AHSD17B10 | |
| SCHEMBL7701199 | 0.76 | MEN1 (1.00) | MEN1KMT2AMAPTRAB9AHSD17B10 | |
| SCHEMBL6173519 | 0.75 | AR (0.52) | MEN1KMT2AMAPTRAB9AL3MBTL1 | |
| SCHEMBL24997232 | 0.74 | POLB (0.59) | MEN1KMT2AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL28744558 | 0.74 | MEN1 (0.69) | MEN1KMT2AMAPTRAB9AHSD17B10 | |
| SCHEMBL6799176 | 0.74 | MAPT (0.68) | MEN1KMT2AMAPTRAB9AHSD17B10 | |
| SCHEMBL6177616 | 0.72 | LIPE (0.46) | L3MBTL1POLBPIM1PIM2 | |
| SCHEMBL1897022 | 0.71 | GRIA1 (0.60) | CYP1A2NOTUM | |
| SCHEMBL125195 | 0.71 | MAPT (1.00) | MEN1KMT2AMAPTRAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025104154-A1 | 5-[2,7-DIAZASPIRO[3.5]NONAN-7-YL]-5-[4-PHENOXYPHENYL]HEXAHYDROPYRIMIDINE-2,4,6-TRIONE DERIVATIVES AS MMP9 INHIBITORS FOR THE TREATMENT OF DRY EYE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2025-05-22 | — | — | WO | disclosed |