Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821181 | 0.85 | MEN1 (0.54) | MGLLNAMPTSMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL31579580 | 0.85 | SMN1; SMN2 (0.47) | MGLLSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL23673734 | 0.83 | STS (0.55) | STSSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL31579558 | 0.83 | YAP1 (0.48) | MGLLSTSSMN1; SMN2NPC1RAB9A | |
| SCHEMBL30869854 | 0.82 | MEN1 (0.52) | MGLLSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL34473416 | 0.79 | SMN1; SMN2 (0.57) | STSSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL17328229 | 0.79 | MGLL (0.70) | MGLLNAMPTGPR119MEN1KMT2A | |
| SCHEMBL13954406 | 0.78 | GPR119 (0.67) | STSSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL31579450 | 0.77 | SMN1; SMN2 (0.46) | MGLLSTSSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4978146 | 0.77 | STS (0.48) | STSSMN1; SMN2NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025104154-A1 | 5-[2,7-DIAZASPIRO[3.5]NONAN-7-YL]-5-[4-PHENOXYPHENYL]HEXAHYDROPYRIMIDINE-2,4,6-TRIONE DERIVATIVES AS MMP9 INHIBITORS FOR THE TREATMENT OF DRY EYE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2025-05-22 | — | — | WO | disclosed |