SCHEMBL31580025

SCHEMBL31580025

FC(F)(F)c1cc(Cl)cc(Br)c1I

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EPAS1 Q99814 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
RAB9A P51151 1/20 0.33
PDK2 Q15119 1/20 0.33
SOS1 Q07889 1/20 0.32
TMPRSS4 Q9NRS4 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29559953 0.77 SOS1 (0.36) EPAS1SOS1
SCHEMBL10215752 0.77 ADRB2 (0.41) EPAS1PDK2
SCHEMBL22866807 0.77 SOS1 (0.36) EPAS1SOS1
SCHEMBL23648094 0.77 TSHR (0.41)
SCHEMBL26695041 0.75 GAA (0.42) SOS1
SCHEMBL31288562 0.75 GAA (0.42) SOS1
SCHEMBL20973548 0.75 ERN1 (0.46) EPAS1CYP1A2CYP2D6CYP2C19RAB9A
SCHEMBL29508536 0.75 ALDH1A1 (0.37) CYP1A2CYP2D6CYP2C19RAB9ATMPRSS4
SCHEMBL22655068 0.75 ALDH1A1 (0.37) CYP1A2CYP2D6CYP2C19RAB9ATMPRSS4
SCHEMBL2948443 0.71 NPC1 (0.33) RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025104443-A1 INHIBITORY COMPOUNDS STORM THERAPEUTICS LTD (GB) 2025-05-22 WO disclosed