Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.53 |
| ▸ | CTSS | P25774 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3159973 | 0.87 | CTSK (0.49) | CTSKCTSSMAPK1TSHRIDO1 | |
| SCHEMBL27129801 | 0.83 | CTSS (0.56) | CTSKCTSSMAPK1TSHRIDO1 | |
| SCHEMBL5891513 | 0.83 | CTSS (0.56) | CTSKCTSSMAPK1TSHRIDO1 | |
| SCHEMBL27002602 | 0.83 | CTSS (0.56) | CTSKCTSSMAPK1TSHRIDO1 | |
| SCHEMBL956164 | 0.82 | CTSS (0.68) | CTSKCTSSIDO1AAK1CTSL | |
| SCHEMBL1351322 | 0.82 | CTSS (0.68) | CTSKCTSSIDO1AAK1CTSL | |
| SCHEMBL956167 | 0.82 | CTSS (0.68) | CTSKCTSSIDO1AAK1CTSL | |
| SCHEMBL3170253 | 0.81 | ALDH1A1 (0.54) | CTSKCTSSTSHRKMT2A | |
| SCHEMBL2748421 | 0.81 | CTSS (0.54) | CTSKCTSSMAPK1TSHRIDO1 | |
| SCHEMBL21571163 | 0.81 | CTSS (0.54) | CTSKCTSSMAPK1TSHRIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1862457-B1 | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | SMITHKLINE BEECHAM CORP (US) | 2010-01-20 | — | — | EP | disclosed |
| EP-1862457-A2 | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | SmithKline Beecham Corporation (US) | 2007-12-05 | — | — | EP | disclosed |
| EP-1406873-B1 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-09-26 | — | — | EP | disclosed |