⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3158483 | 1.00 | — | — | |
| SCHEMBL8242579 | 0.77 | — | — | |
| SCHEMBL1680319 | 0.77 | — | — | |
| SCHEMBL9530279 | 0.77 | ALDH1A1 (0.42) | — | |
| SCHEMBL23608992 | 0.74 | — | — | |
| SCHEMBL28770002 | 0.73 | — | — | |
| SCHEMBL24922425 | 0.73 | RAB9A (0.40) | — | |
| SCHEMBL20511632 | 0.70 | NPC1 (0.38) | — | |
| SCHEMBL25284844 | 0.70 | NPC1 (0.38) | — | |
| SCHEMBL20559575 | 0.70 | NPC1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753719-B1 | SUBSTITUTED PYRROLIDINE-2-ONES | NOVARTIS AG (CH) | 2010-03-03 | — | — | EP | disclosed |
| US-20070172421-A1 | Substituted pyrrolidine-2-ones | NOVARTIS AG (CH) | 2007-07-26 | — | — | US | disclosed |
| EP-1753719-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | Novartis AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005118535-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | NOVARTIS AG (CH) | 2005-12-15 | — | — | WO | disclosed |